Description

9-β-D-Arabinofuranosyl-9H-Purine-6-Thiol Triacetate Ester is a key nucleoside derivative and a protected intermediate of significant value in pharmaceutical research and development. This compound is crucial for the synthesis of modified nucleosides and nucleotides, enabling the creation of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral and anticancer drugs, as well as in advanced biochemical studies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer agents.
• Antiviral Drug Research: Serves as a precursor in the development of nucleoside analogues that target viral polymerases.
• Oncology Research: Used in the design and synthesis of chemotherapeutic compounds that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Probe Development: Employed to create labeled or modified nucleotides for studying enzymatic mechanisms and nucleic acid interactions.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for complex nucleoside-based therapeutics under GMP conditions.
• Academic Research: A valuable reagent for synthetic organic chemistry and medicinal chemistry projects in university and institutional labs.

Basic Information

Product Name	9-β-D-Arabinofuranosyl-9H-Purine-6-Thiol Triacetate Ester
CAS No.	98028-94-5
Molecular Formula	C₁₆H₁₈N₄O₇S
Molecular Weight	410.40 g/mol
Synonyms	6-Mercaptopurine-9-β-D-arabinofuranoside Triacetate; 6-Thio-9-β-D-arabinofuranosylpurine Triacetate; 9-β-D-Arabinofuranosyl-6-mercaptopurine Triacetate; 6-Thioguanine Arabinoside Triacetate Ester (related analogue); Ara-6-TG Triacetate; 9H-Purine-6-thiol, 9-β-D-arabinofuranosyl-, triacetate; 6-MP Arabinoside Triacetate; NSC 49193 (Potential NSC Number)
EINECS	Contact for details

Quality Control

Our 9-β-D-Arabinofuranosyl-9H-Purine-6-Thiol Triacetate Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic and spectral data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.