Description

(5S)-5-(Hydroxymethyl)-1,3-Oxazolidin-2-One is a high-purity chiral oxazolidinone derivative, a critical building block in modern asymmetric synthesis. This compound matters as a versatile intermediate for constructing complex pharmaceutical molecules, particularly antibiotics and other active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of oxazolidinone-class antibiotics, such as linezolid and tedizolid.
• Asymmetric Synthesis: Acts as a chiral auxiliary or building block in stereoselective reactions to introduce specific stereochemistry into target molecules.
• API Development: Used in research and process development for novel Active Pharmaceutical Ingredients (APIs) requiring the (5S)-hydroxymethyl oxazolidinone motif.
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex, high-value specialty chemicals and agrochemicals.
• Academic & Industrial Research: Valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	(5S)-5-(Hydroxymethyl)-1,3-Oxazolidin-2-One
CAS No.	97859-51-3
Molecular Formula	C4H7NO3
Molecular Weight	117.10 g/mol
Synonyms	(S)-5-(Hydroxymethyl)-2-oxazolidinone; (S)-(-)-5-Hydroxymethyl-2-oxazolidinone; (5S)-Hydroxymethyloxazolidin-2-one; L-5-Hydroxymethyl-2-oxazolidinone; (S)-5-Hydroxymethyloxazolidin-2-one; (S)-HMTO; (S)-HMO; Chiral Oxazolidinone Building Block
EINECS	Contact for details

Quality Control

Our (5S)-5-(Hydroxymethyl)-1,3-Oxazolidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-grade standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.