Description

1-Bromoestradiol is a halogenated derivative of the natural estrogen hormone estradiol, specifically modified at the 1-position with a bromine atom. This structural modification is of significant interest for its utility as a key synthetic intermediate in the development of novel steroid-based pharmaceuticals and research compounds. It is primarily sought after by research institutions and pharmaceutical companies engaged in steroid chemistry, medicinal chemistry, and the development of hormone receptor modulators. The compound, identified by CAS NO 97794-69-9, offers a versatile building block for creating targeted molecules with potential therapeutic applications.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel steroidal drugs and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a molecular scaffold for structure-activity relationship (SAR) studies to develop new estrogen receptor ligands.
• Biochemical Tool Compound: Employed in laboratory research to study steroid metabolism, hormone signaling pathways, and receptor interactions.
• Organic Synthesis: Acts as a specialized starting material for the preparation of other brominated or functionalized steroid analogs.
• Reference Standard: Can be utilized as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	1-Bromoestradiol
CAS No.	97794-69-9
Molecular Formula	C18H23BrO2
Molecular Weight	351.28 g/mol
Synonyms	1-Bromoestra-1,3,5(10)-triene-3,17β-diol; 1-Bromo-17β-estradiol; 1-Bromo-E2; Estra-1,3,5(10)-triene-3,17-diol, 1-bromo-; 1-Bromo-1,3,5(10)-estratriene-3,17β-diol
EINECS	Contact for details

Quality Control

Our 1-Bromoestradiol is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.