Description

n-Desmethyl Ofloxacin is a key pharmaceutical intermediate and metabolite of the fluoroquinolone antibiotic ofloxacin. Its primary value lies in its critical role in the research, development, and quality control of antibacterial agents. This compound is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on antibiotic metabolism, impurity profiling, and the synthesis of advanced drug substances.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis and development of advanced fluoroquinolone antibiotics and their derivatives.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical testing.
• Metabolite Studies: Employed in pharmacokinetic and pharmacodynamic research to study the metabolism, bioavailability, and excretion pathways of ofloxacin.
• Impurity Profiling: Serves as a known impurity standard to monitor and control the quality of ofloxacin active pharmaceutical ingredients (APIs) and finished drug products according to ICH guidelines.
• Biochemical Research: Utilized in microbiological and enzymatic studies to investigate the mechanism of action and resistance of quinolone antibiotics.

Basic Information

Product Name	n-Desmethyl Ofloxacin
CAS No.	97791-27-0
Molecular Formula	C17H19FN4O4
Molecular Weight	362.36 g/mol
Synonyms	9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic Acid; Desmethyl Ofloxacin; Ofloxacin Impurity C; Ofloxacin N-Oxide Impurity; Ofloxacin Related Compound C; 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid N-Oxide
EINECS	Contact for details

Quality Control

Our n-Desmethyl Ofloxacin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and MS, to ensure it meets high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.