Description

Boc-Arg(Boc)2-Oh CAS NO 97745-69-2 is a protected derivative of the amino acid L-Arginine, featuring three tert-butoxycarbonyl (Boc) protecting groups. This compound is critically important as a high-purity building block in solid-phase peptide synthesis (SPPS) and other advanced organic synthesis workflows. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers developing therapeutic peptides, diagnostic agents, and complex bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid monomer for the controlled, sequential assembly of peptide chains, particularly those containing arginine residues.
• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Labeling: Used in the preparation of modified peptides for bioconjugation, fluorescent labeling, or the attachment of other functional groups.
• Research & Development: Essential reagent in academic and industrial research for studying protein-protein interactions, enzyme substrates, and peptide hormones.
• Custom Peptide Production: Employed by CROs and CDMOs for the reliable and scalable manufacture of custom peptides for clients.
• Protecting Group Strategy: The orthogonal Boc protection allows for selective deprotection in multi-step syntheses involving other protecting groups like Fmoc.

Basic Information

Product Name	Boc-Arg(Boc)2-Oh
CAS No.	97745-69-2
Molecular Formula	C₂₂H₄₂N₄O₈
Molecular Weight	490.60 g/mol
Synonyms	Nα,Nω,Nω'-Tris(tert-butoxycarbonyl)-L-arginine; Nα-Boc-Nω,Nω'-di-Boc-L-arginine; Boc-Arg(Boc)2-OH; Boc-L-Arg(Boc)2-OH; (2S)-5-[(tert-Butoxycarbonyl)amino]-2-[(tert-butoxycarbonyl)amino]pentanoic acid 1-[(tert-butoxycarbonyl)amino]-4-guanidinobutyl ester; H-Arg(Boc)2-OH Boc; L-Arginine, N2,N5-bis[(1,1-dimethylethoxy)carbonyl]-N-[(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Boc-Arg(Boc)2-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.