Description

Rac Desmethyl Citalopram Hydrochloride CAS NO 97743-99-2 is a key chiral intermediate and reference standard in pharmaceutical research and development. This compound is of critical importance for the synthesis and analytical characterization of active pharmaceutical ingredients (APIs) and their metabolites within the selective serotonin reuptake inhibitor (SSRI) class. It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical manufacturers engaged in process development, quality control, and regulatory compliance activities.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the identification, assay, and impurity profiling of citalopram and related compounds in HPLC, GC, and LC-MS analyses.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a crucial chiral building block in the synthetic pathways for developing novel SSRIs and for the production of desmethylcitalopram.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research, enabling the study of drug metabolism pathways and the biological activity of metabolites.
• Process Chemistry & Impurity Synthesis: Employed in the development and validation of manufacturing processes, including the synthesis of specified impurities for qualification studies.
• Analytical Method Development: A critical component for developing and validating chromatographic and spectroscopic methods in compliance with ICH guidelines.
• Regulatory Documentation: Provides essential data for regulatory filings (e.g., FDA, EMA) to establish identity, purity, and stability of drug substances.

Basic Information

Product Name	Rac Desmethyl Citalopram Hydrochloride
CAS No.	97743-99-2
Molecular Formula	C19H21FN2O•HCl
Molecular Weight	348.84 g/mol
Synonyms	1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Hydrochloride; (±)-Desmethylcitalopram Hydrochloride; Rac-Desmethylcitalopram HCl; Lu 10-131-A; N-Desmethylcitalopram Hydrochloride; Didesmethylcitalopram Impurity; Citalopram Desmethyl Metabolite
EINECS	Contact for details

Quality Control

Our Rac Desmethyl Citalopram Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via advanced techniques like HPLC and GC to ensure high purity and batch-to-batch consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent specifications. We support our clients' needs for regulatory submissions with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.