Description

Mitoxantrone Carboxylic Acid is a key pharmaceutical intermediate and synthetic precursor of significant commercial and research importance. Its primary value lies in its role as a critical building block for the synthesis of Mitoxantrone, a potent antineoplastic agent, ensuring high-purity supply is essential for downstream drug manufacturing. This compound is primarily needed by pharmaceutical R&D laboratories, active pharmaceutical ingredient (API) manufacturers, and fine chemical suppliers serving the oncology therapeutics sector.

Application

• Pharmaceutical Intermediate: Primary use as a crucial precursor in the multi-step synthesis of the chemotherapeutic drug Mitoxantrone Hydrochloride.
• Oncology Drug Research: Serves as a key starting material or reference standard in the research and development of novel anthracenedione-based anticancer agents.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in controlled GMP environments for the commercial-scale production of Mitoxantrone API.
• Biochemical Research: Used in studies investigating the structure-activity relationships (SAR) and mechanism of action of topoisomerase II inhibitors.
• Fine Chemical Synthesis: Acts as a specialized building block for synthesizing novel chemical entities and analogs for biological screening.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and impurity profiling in pharmaceutical analysis.

Basic Information

Product Name	Mitoxantrone Carboxylic Acid
CAS No.	97729-56-1
Molecular Formula	C22H28N4O6
Molecular Weight	444.48 g/mol
Synonyms	1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione-2-carboxylic Acid; Mitoxantrone Acid; Mitoxantrone-2-carboxylic Acid; Mitoxantrone Impurity; Mitoxantrone Carboxylate; NSC 353451; LH 1; BA 16736; DHAQ-CA
EINECS	Contact for details

Quality Control

Our Mitoxantrone Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for pharmaceutical R&D and synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and mass spectrometry. We adhere to relevant ICH guidelines and can support development projects requiring material manufactured under GMP principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Dark blue to purple solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.