Description

(-)-4,4,8-Trimethyl-18-Nor-15-Oxa-5α-Androsta-13,16-Diene-19-Oic Acid is a high-purity, chiral steroid derivative with a complex, modified androstane skeleton. This compound serves as a critical advanced intermediate in the synthesis of novel pharmaceutical agents, particularly in the development of steroidal drugs targeting hormone receptors and metabolic pathways. It is essential for research institutions and pharmaceutical manufacturers engaged in medicinal chemistry, process development, and the production of specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel steroidal drugs and hormone analogs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new therapeutic agents with modified biological activity.
• Process Development: Serves as a reference standard and starting material for scaling up synthetic routes in API manufacturing.
• Biochemical Research: Investigated for its interaction with steroid hormone receptors and enzymes in metabolic studies.
• Fine Chemical Synthesis: Employed in the production of complex, high-value specialty chemicals for advanced applications.

Basic Information

Item	Details
Product Name	(-)-4,4,8-Trimethyl-18-Nor-15-Oxa-5α-Androsta-13,16-Diene-19-Oic Acid
CAS No.	97640-44-3
Molecular Formula	C₂₁H₃₀O₃
Molecular Weight	330.46 g/mol
Synonyms	19-Nor-15-oxa-5α-androsta-13,16-diene-19-oic acid, 4,4,8-trimethyl-, (5α)-; 97640-44-3; 15-Oxa-19-norandrosta-13,16-diene-19-oic acid derivative; Modified Androstane Derivative; Steroid Carboxylic Acid Intermediate; (5α)-4,4,8-Trimethyl-18-nor-15-oxaandrosta-13,16-diene-19-oic acid
EINECS	Contact for details

Quality Control

Our (-)-4,4,8-Trimethyl-18-Nor-15-Oxa-5α-Androsta-13,16-Diene-19-Oic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product should be kept under an inert atmosphere if long-term storage is required to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.