Description

3,5-Bis(Trifluoromethyl)Benzamidine Hydrochloride is a high-value, fluorinated amidine derivative that serves as a critical building block in advanced organic synthesis. Its core value lies in the unique reactivity of the amidine group and the electronic properties imparted by the trifluoromethyl substituents, enabling the construction of complex heterocyclic and pharmaceutical scaffolds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule drug candidates, especially those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl groups contribute to lipophilicity and biological activity.
• Ligand and Catalyst Preparation: Serves as a starting material for creating nitrogen-donor ligands used in transition metal catalysis and organocatalysis.
• Heterocyclic Chemistry: Fundamental building block for constructing pyrimidines, triazines, and other nitrogen-containing heterocycles prevalent in medicinal and material chemistry.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic frameworks (e.g., MOFs, COFs) for specialized applications.
• Chemical Biology Probes: Useful for creating labeled compounds and activity-based probes for studying enzymatic mechanisms and biological pathways.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Benzamidine Hydrochloride
CAS No.	97603-94-6
Molecular Formula	C9H5ClF6N2
Molecular Weight	290.59 g/mol
Synonyms	3,5-Bis(trifluoromethyl)benzenecarboximidamide hydrochloride; 3,5-Bis(trifluoromethyl)benzamidine HCl; Benzenecarboximidamide, 3,5-bis(trifluoromethyl)-, hydrochloride; 3,5-Di(trifluoromethyl)benzamidine hydrochloride; 3,5-Bis(trifluoromethyl)benzamidine monohydrochloride; 97603-94-6; Amidino-3,5-bis(trifluoromethyl)benzene hydrochloride
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Benzamidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions (e.g., nitrogen or argon atmosphere) when opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.