Description

Boc-α-Methyl-Dl-Leucine CAS NO 97534-52-6 is a protected, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group and an α-methyl modification. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering enhanced metabolic stability and conformational control. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing novel therapeutic agents and bioactive molecules.

Application

• Pharmaceutical Intermediates: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate non-natural amino acids into peptide chains.
• Protease Inhibitor Development: A valuable precursor for creating inhibitors that target specific enzymes due to its modified, non-hydrolyzable structure.
• Chemical Biology Research: Employed in studying protein-protein interactions and designing peptide-based probes and tools.
• Material Science: Potential use in the synthesis of specialized polymers and biomaterials with tailored properties.

Basic Information

Product Name	Boc-α-Methyl-Dl-Leucine
CAS No.	97534-52-6
Molecular Formula	C₁₂H₂₃NO₄
Molecular Weight	245.32 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-α-methyl-DL-leucine; Boc-α-Me-DL-Leu-OH; 2-[(2-Methylpropyl)(methyl)amino]-2-oxoacetic acid, 1,1-dimethylethyl ester; tert-Butyl (α-methyl-DL-leucinyl)carbamate; DL-2-(tert-Butoxycarbonylamino)-2-methylpentanoic acid; N-Boc-α-methylleucine; Boc-Aminoisobutyric acid derivative; (RS)-2-[(tert-Butoxycarbonyl)amino]-2-methylpentanoic acid
EINECS	Contact for details

Quality Control

Our Boc-α-Methyl-Dl-Leucine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure it meets high-grade research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	DL-mixture (Racemic)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.