Description

S-Phenylsulfonylcysteine is a specialized cysteine derivative featuring a phenylsulfonyl protecting group. This compound is a critical building block and intermediate in advanced organic synthesis, particularly in the development of pharmaceuticals and bioactive peptides. It is primarily utilized by research institutions and manufacturers in the life sciences sector for drug discovery and process chemistry applications. The product is supplied to meet the stringent purity requirements of these industries.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting cysteine protease enzymes or requiring specific thiol protection/deprotection strategies.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected cysteine residue to prevent unwanted disulfide bond formation or side reactions during coupling steps.
• Bioconjugation: Serves as a reagent for introducing sulfonyl-protected thiol groups into biomolecules for subsequent labeling, linker attachment, or controlled release applications.
• Chemical Biology Research: Employed as a tool compound in studying enzyme mechanisms, protein interactions, and redox biology where a protected, yet activatable, cysteine analog is required.
• Process Development: Used in scaling up synthetic routes for active pharmaceutical ingredients (APIs) that incorporate modified cysteine units.

Basic Information

Product Name	S-Phenylsulfonylcysteine
CAS No.	97512-83-9
Molecular Formula	C9H11NO4S2
Molecular Weight	261.32 g/mol
Synonyms	L-Cysteine, S-(phenylsulfonyl)-; (R)-2-Amino-3-(phenylsulfonylthio)propanoic acid; S-Phenylsulfonyl-L-cysteine; Phenylsulfonylcysteine; NSC 339586; 97512-83-9; L-Cysteine S-(phenylsulfonyl) derivative
EINECS	Contact for details

Quality Control

Our S-Phenylsulfonylcysteine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and cGMP-grade requirements as needed.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.