Description

2H-Pyran-2-One, 6-(3,4-Dihydroxyphenyl)-5,6-Dihydro-, (S)- (9Ci) is a chiral dihydroisocoumarin derivative, a key structural motif in natural products and synthetic chemistry. This compound matters as a versatile chiral building block for the synthesis of complex molecules, particularly in pharmaceutical research where stereochemical purity is critical. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis and as a precursor to bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially those targeting neurological or metabolic pathways.
• Asymmetric Catalysis Research: Used as a substrate or ligand precursor in the study and development of new asymmetric catalytic reactions.
• Natural Product Synthesis: Acts as a key intermediate in the total synthesis of complex natural products containing the dihydroisocoumarin scaffold.
• Agrochemical Development: Employed in the research and synthesis of new chiral agrochemicals, such as fungicides or plant growth regulators.
• Flavor & Fragrance Chemistry: Potential use as a precursor for synthesizing specific lactone-based aroma compounds.
• Biochemical Research: Can be utilized as a standard or probe in enzymatic studies related to polyphenol metabolism.

Basic Information

Product Name	2H-Pyran-2-One, 6-(3,4-Dihydroxyphenyl)-5,6-Dihydro-, (S)- (9Ci)
CAS No.	97457-16-4
Molecular Formula	C11H10O4
Molecular Weight	206.19 g/mol
Synonyms	(S)-6-(3,4-Dihydroxyphenyl)-5,6-dihydro-2H-pyran-2-one; (S)-5,6-Dihydro-6-(3,4-dihydroxyphenyl)-2H-pyran-2-one; (S)-Dihydrocaffeic acid lactone; (S)-3,4-Dihydroxybenzodihydropyrone; (S)-Hexahydrocurcumin lactone isomer; L-Dihydrocaffeic acid δ-lactone; (S)-Form of CAS 97457-16-4
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥97% (by HPLC), with chiral purity (Enantiomeric Excess) being a critical control parameter. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are available upon request. Our quality system supports development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.