Description

1-(5-Methoxy-2-[(Trimethylsilyl)Oxy]Phenyl)Ethanone is a high-purity, protected phenolic ketone intermediate of significant importance in advanced organic synthesis. Its core value lies in its dual functionality, where the trimethylsilyl (TMS) group acts as a protective moiety for the phenolic hydroxyl, enabling selective reactions at the acetyl group. This compound is essential for research chemists and process development scientists in the pharmaceutical and fine chemical industries who require reliable, high-quality building blocks for complex molecule assembly, such as in the synthesis of novel drug candidates and specialty materials.

Application

• Pharmaceutical Intermediate: A key protected precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly those containing substituted benzophenone or chalcone scaffolds.
• Organic Synthesis Building Block: Used in reactions like Friedel-Crafts acylation, Grignard additions, and cross-coupling reactions where selective deprotection of the TMS group is required.
• Agrochemical Research: Serves as an intermediate in the development of new herbicides, fungicides, and plant growth regulators that utilize methoxy-substituted aromatic ketone structures.
• Material Science Precursor: Employed in the research and development of organic electronic materials, ligands for catalysts, and advanced polymers.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in synthetic organic chemistry, especially in projects involving protective group strategies.

Basic Information

Product Name	1-(5-Methoxy-2-[(Trimethylsilyl)Oxy]Phenyl)Ethanone
CAS No.	97389-71-4
Molecular Formula	C12H18O3Si
Molecular Weight	238.36 g/mol
Synonyms	2'-Hydroxy-5'-methoxyacetophenone trimethylsilyl ether; 1-(5-Methoxy-2-((trimethylsilyl)oxy)phenyl)ethan-1-one; 2-(Trimethylsiloxy)-5-methoxyacetophenone; 5-Methoxy-2-(trimethylsiloxy)acetophenone; 2-Acetyl-4-methoxyphenyl trimethylsilyl ether; TMS Ether of 2'-Hydroxy-5'-methoxyacetophenone; 97389-71-4; Ethanone, 1-[5-methoxy-2-[(trimethylsilyl)oxy]phenyl]-
EINECS	Contact for details

Quality Control

Our 1-(5-Methoxy-2-[(Trimethylsilyl)Oxy]Phenyl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.