Description

Proline, 5-Methyl-, Methyl Ester, trans- (9Ci) is a high-purity, non-natural proline derivative characterized by its specific stereochemistry and ester functionalization. This compound is a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecules with precise stereochemical control. It is essential for research and development in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients, peptides, and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in protease inhibitor and peptide-mimetic research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators requiring specific stereoisomers for optimal activity.
• Peptide Chemistry: Serves as a modified amino acid building block for introducing conformational constraints and enhancing the metabolic stability of therapeutic peptides.
• Asymmetric Catalysis: Employed as a precursor for chiral ligands and organocatalysts used in stereoselective transformations.
• Fine Chemical Production: A versatile intermediate for manufacturing specialty chemicals, flavors, and fragrances.
• Academic & Industrial R&D: A valuable reference standard and starting material for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	Proline, 5-Methyl-, Methyl Ester, trans- (9Ci)
CAS No.	97373-39-2
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	trans-5-Methyl-L-proline methyl ester; (2S,5R)-5-Methylpyrrolidine-2-carboxylic acid methyl ester; Methyl (2S,5R)-5-methylprolinate; L-Proline, 5-methyl-, methyl ester, trans-; Methyl trans-5-methyl-L-prolinate; (2S,5R)-Methyl 5-methylprolinate; 5-Methylproline methyl ester
EINECS	Contact for details

Quality Control

Our Proline, 5-Methyl-, Methyl Ester, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ISO standards for research and production use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.