Description

Proline, 3,5-Dimethyl-, Methyl Ester, (2-α-,3-α-,5-α-)- (9Ci) is a specialized, high-purity chiral proline derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing a sterically defined, functionalized proline scaffold essential for constructing complex molecules with precise stereochemistry. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), asymmetric catalysts, and peptidomimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and metabolic disease targets.
• Asymmetric Catalysis: Used as a precursor or ligand in the design of organocatalysts for enantioselective synthesis, enabling the production of single-isomer compounds.
• Peptidomimetic Design: Incorporated into peptide analogs to enhance metabolic stability, bioavailability, and receptor binding affinity.
• Agrochemical Research: Employed in the synthesis of novel, chiral active ingredients for crop protection products.
• Academic & Process Chemistry: Serves as a valuable tool for methodological development in stereochemistry and scalable synthetic route design.
• Fine Chemical Synthesis: Used in the production of other high-value, specialty chemicals requiring a defined proline-based stereocenter.

Basic Information

Product Name	Proline, 3,5-Dimethyl-, Methyl Ester, (2-α-,3-α-,5-α-)- (9Ci)
CAS No.	97347-54-1
Molecular Formula	C9H17NO2
Molecular Weight	171.24 g/mol
Synonyms	Methyl (2α,3α,5α)-3,5-dimethylprolinate; (2S,3S,5S)-3,5-Dimethylproline methyl ester; 3,5-Dimethyl-L-proline methyl ester; Methyl 3,5-dimethylprolinate; Proline, 3,5-dimethyl-, methyl ester, (2S,3S,5S)-; A chiral 3,5-disubstituted proline ester
EINECS	Contact for details

Quality Control

Our Proline, 3,5-Dimethyl-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC and structural confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with full batch traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.