Description

Ethyl (S)-α-[(4-Aminophenyl)Methyl]-1,3-Dihydro-1,3-Dioxo-2H-Isoindole-2-Acetate Monohydrochloride is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound is critical for research and development teams requiring precise stereochemistry in active pharmaceutical ingredient (API) manufacturing. It is primarily utilized by pharmaceutical and fine chemical companies engaged in the development of novel therapeutic agents, particularly where the (S)-enantiomer is required for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex APIs, especially for central nervous system (CNS) and cardiovascular drugs.
• Asymmetric Synthesis: Used in research to construct molecules with high enantiomeric purity for biological testing and process development.
• Protease Inhibitor Research: Serves as a precursor or intermediate in the development of protease inhibitor candidates.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development and quality control in pharmaceutical labs.
• Academic & Contract Research: Utilized in university and CRO settings for medicinal chemistry programs and novel synthetic route exploration.
• Process Chemistry Optimization: Acts as a critical material for scaling up and optimizing commercial manufacturing processes for target molecules.

Basic Information

Product Name	Ethyl (S)-α-[(4-Aminophenyl)Methyl]-1,3-Dihydro-1,3-Dioxo-2H-Isoindole-2-Acetate Monohydrochloride
CAS No.	97338-03-9
Molecular Formula	C19H18N2O4•HCl
Molecular Weight	374.82 g/mol (Free base: 338.36 g/mol)
Synonyms	(S)-Ethyl 2-((4-aminobenzyl)(1,3-dioxoisoindolin-2-yl))acetate hydrochloride; (S)-N-Phthaloyl-4-aminophenylalanine ethyl ester hydrochloride; Ethyl (S)-α-[(4-aminophenyl)methyl]-1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetate hydrochloride; (S)-2-[(4-Aminobenzyl)(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)]acetic acid ethyl ester hydrochloride; N-[(S)-1-Ethoxycarbonyl-2-(4-aminophenyl)ethyl]phthalimide hydrochloride; (S)-N-Phthaloyl-p-aminophenylalanine ethyl ester HCl; A protected (S)-4-aminophenylalanine derivative
EINECS	Contact for details

Quality Control

Our Ethyl (S)-α-[(4-Aminophenyl)Methyl]-1,3-Dihydro-1,3-Dioxo-2H-Isoindole-2-Acetate Monohydrochloride is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each batch to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.