Description

Ethyl (S)-α-[[4-[Bis(2-Hydroxyethyl)Amino]Phenyl]Methyl]-1,3-Dihydro-1,3-Dioxo-2H-Isoindole-2-Acetate is a high-purity chiral intermediate featuring a phthalimide core and a diethanolamine-substituted phenyl group. This compound matters for its role as a critical building block in the synthesis of complex, biologically active molecules, offering precise stereochemical control. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers developing advanced therapeutics, including enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and metabolic disease research.
• Protease Inhibitor Synthesis: Serves as a core structural component in the synthesis of potent protease inhibitors.
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct complex molecular architectures with high enantiomeric purity.
• Bioconjugation & Probe Development: The reactive ester and aromatic amine functionalities make it suitable for creating fluorescent probes or targeted drug conjugates.
• Chemical Biology Research: Used in academic and industrial labs to study enzyme-substrate interactions and signal transduction pathways.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals requiring high fidelity and specific stereochemistry.

Basic Information

Product Name	Ethyl (S)-α-[[4-[Bis(2-Hydroxyethyl)Amino]Phenyl]Methyl]-1,3-Dihydro-1,3-Dioxo-2H-Isoindole-2-Acetate
CAS No.	97338-02-8
Molecular Formula	C23H24N2O6
Molecular Weight	424.45 g/mol
Synonyms	(S)-Ethyl 2-((4-(bis(2-hydroxyethyl)amino)benzyl)(1,3-dioxoisoindolin-2-yl)acetate; Ethyl (S)-2-((4-(bis(2-hydroxyethyl)amino)benzyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-2-acetate; (S)-N-Phthaloyl-4-(bis(2-hydroxyethyl)amino)phenylalanine Ethyl Ester; 97338-02-8; (S)-N-Phth-Phe(4-NEt(OH)2)-OEt; A Chiral Phthalimide Derivative
EINECS	Contact for details

Quality Control

Our Ethyl (S)-α-[[4-[Bis(2-Hydroxyethyl)Amino]Phenyl]Methyl]-1,3-Dihydro-1,3-Dioxo-2H-Isoindole-2-Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess and NMR for structural confirmation, to ensure compliance with exacting R&D and cGMP standards for pharmaceutical intermediates. Certificates of Analysis (COA) with full chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.