Description

Proline, 3-Fluoro-5-Oxo-, Methyl Ester, trans- (9Ci) is a high-purity, fluorinated proline derivative, specifically engineered as a critical chiral building block for advanced organic synthesis. This compound is valued for its unique structural features, which enable precise stereochemical control and the introduction of fluorine atoms into complex target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated drug candidates, including protease inhibitors and other biologically active molecules.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated pesticides and herbicides where the fluorine atom enhances stability and bioactivity.
• Peptidomimetics & Bio-conjugates: Serves as a modified amino acid residue for constructing peptide analogs with improved metabolic stability and binding affinity.
• Asymmetric Catalysis Research: Employed as a ligand precursor or a test substrate in the development of new catalytic systems for stereoselective transformations.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes to study enzyme mechanisms and protein interactions.
• Material Science: Potential monomer for specialty polymers where fluorination imparts specific physical properties like hydrophobicity or chemical resistance.

Basic Information

Product Name	Proline, 3-Fluoro-5-Oxo-, Methyl Ester, trans- (9Ci)
CAS No.	97315-83-8
Molecular Formula	C7H10FNO3
Molecular Weight	175.16 g/mol
Synonyms	trans-3-Fluoro-5-oxoproline methyl ester; Methyl (2S,3R)-3-fluoro-5-oxopyrrolidine-2-carboxylate; (2S,3R)-3-Fluoro-5-oxopyrrolidine-2-carboxylic acid methyl ester; 3-Fluoro-5-oxo-L-proline methyl ester (trans); trans-3-Fluoropyroglutamic acid methyl ester; Fluoroproline derivative; 97315-83-8
EINECS	Contact for details

Quality Control

Every batch of Proline, 3-Fluoro-5-Oxo-, Methyl Ester, trans- (9Ci) is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as chiral purity (enantiomeric excess), chemical purity (HPLC), and identity confirmation (NMR, IR).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.