Description

2-[(Trimethylsilyl)Ethynyl]Benzonitrile is a versatile organosilicon building block featuring a trimethylsilyl-protected alkyne group ortho to a nitrile functionality on a benzene ring. This unique bifunctional structure makes it a valuable intermediate for constructing complex molecular architectures in advanced organic synthesis. It is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and materials science industries for applications in cross-coupling reactions, click chemistry, and as a precursor to heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of novel active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides, leveraging its reactivity to introduce complex side chains.
• Material Science Precursor: Serves as a monomer or building block for functional polymers, liquid crystals, and organic electronic materials due to its conjugated system.
• Cross-Coupling Reactions: The protected alkyne and aromatic bromide (if present in derivatives) are ideal for Sonogashira, Suzuki, and other palladium-catalyzed coupling reactions.
• Click Chemistry: The alkyne group, after deprotection, is a prime candidate for Huisgen 1,3-dipolar cycloaddition (copper-catalyzed azide-alkyne cycloaddition) to create triazole linkages.
• Ligand and Catalyst Development: Employed in the synthesis of novel chelating ligands and organometallic catalysts for asymmetric synthesis.

Basic Information

Product Name	2-[(Trimethylsilyl)Ethynyl]Benzonitrile
CAS No.	97308-62-8
Molecular Formula	C12H13NSi
Molecular Weight	199.33 g/mol
Synonyms	2-((Trimethylsilyl)ethynyl)benzonitrile; 2-(Trimethylsilylethynyl)benzonitrile; Benzonitrile, 2-[(trimethylsilyl)ethynyl]-; 2-(Trimethylsilylethynyl)benzonitrile; 2-(Trimethylsilyl)ethynylbenzonitrile; 2-(TMS-ethynyl)benzonitrile; o-[(Trimethylsilyl)ethynyl]benzonitrile; 2-Cyano-phenyl(trimethylsilyl)acetylene
EINECS	Contact for details

Quality Control

Our 2-[(Trimethylsilyl)Ethynyl]Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.