Description

N(Alpha)-((2-Phenylethyl)Phenoxyphosphoryl)Alanylproline is a specialized synthetic peptide derivative containing a phenoxyphosphoryl group. This compound is significant as a key intermediate or building block in advanced pharmaceutical research and development, particularly for creating novel bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of peptide-based drugs, enzyme inhibitors, and targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel peptide-based drug candidates and prodrugs.
• Protease Inhibitor Research: Used in the development and study of inhibitors for enzymes like prolyl oligopeptidase and other serine proteases.
• Chemical Biology Probes: Employed in the design of activity-based probes (ABPs) to study enzyme function and mechanism in biological systems.
• Medicinal Chemistry: Utilized for structure-activity relationship (SAR) studies to optimize the potency and selectivity of therapeutic compounds.
• Bioconjugation: The reactive phosphoryl group can be leveraged for conjugation strategies in drug delivery system development.
• Academic & Industrial R&D: A valuable reagent for basic research in biochemistry and organic chemistry focused on peptide mimetics and phosphorylated compounds.

Basic Information

Product Name	N(Alpha)-((2-Phenylethyl)Phenoxyphosphoryl)Alanylproline
CAS No.	97280-48-3
Molecular Formula	C22H25N2O5P
Molecular Weight	428.42 g/mol
Synonyms	N-[(2-Phenylethoxy)(phenoxy)phosphoryl]alanylproline; (2S)-1-[(2S)-2-[[(2-Phenylethoxy)(phenoxy)phosphoryl]amino]propanoyl]pyrrolidine-2-carboxylic acid; Alanylproline, N-[phenoxy(2-phenylethoxy)phosphinyl]-; PEP-Ala-Pro; N(Alpha)-(Phenoxy(2-phenylethoxy)phosphinyl)alanylproline; Proline, N-[N-[phenoxy(2-phenylethoxy)phosphinyl]alanyl]-
EINECS	Contact for details

Quality Control

Our N(Alpha)-((2-Phenylethyl)Phenoxyphosphoryl)Alanylproline is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.