Description

Desethyl Acetate (E)-Cefuroxime Axetil is a key pharmaceutical intermediate in the synthesis of the second-generation cephalosporin antibiotic, Cefuroxime Axetil. This compound is critical for ensuring the purity, efficacy, and regulatory compliance of the final active pharmaceutical ingredient (API). It is primarily required by manufacturers in the pharmaceutical and fine chemical industries engaged in the production of advanced antibiotic formulations.

Application

• Pharmaceutical Intermediate: Primary use as a crucial synthetic precursor in the commercial production of Cefuroxime Axetil API.
• Antibiotic Synthesis: Integral component in multi-step synthesis pathways for β-lactam antibiotics.
• Research & Development: Used in analytical laboratories and R&D facilities for method development, impurity profiling, and reference standard preparation.
• Process Chemistry: Employed in scale-up and optimization studies for robust and cost-effective API manufacturing processes.
• Quality Control: Serves as a critical reference material for identifying and quantifying related substances in final drug products.
• Generic Drug Manufacturing: Essential for companies developing bioequivalent generic versions of cephalosporin-based medications.

Basic Information

Product Name	Desethyl Acetate (E)-Cefuroxime Axetil
CAS No.	97232-97-8
Molecular Formula	C18H19N5O8S
Molecular Weight	465.44 g/mol
Synonyms	(6R,7R)-7-[(Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetamido]-3-[(E)-2-(acetoxymethoxycarbonylethenyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; (E)-Isomer of Cefuroxime Axetil Desethyl Acetate; Desacetyl Cefuroxime Axetil (E)-Isomer; Cefuroxime Axetil Impurity; Cefuroxime Axetil Related Compound E; 1-Acetoxyethyl (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[(E)-2-carboxyvinyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (Hydrolyzed Ester); SQ 82,992 (E)-Isomer
EINECS	Contact for details

Quality Control

Our Desethyl Acetate (E)-Cefuroxime Axetil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and conformity to stringent specifications. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific pharmacopeial standards (e.g., USP, EP) or customer requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.