Description

8-Amino-6-Fluoro-9-Ribofuranosyl-9H-Purine is a fluorinated nucleoside analog, a key building block in medicinal chemistry and pharmaceutical research. Its unique structure, featuring a fluorine atom at the 6-position and an amino group at the 8-position of the purine ring, makes it a valuable precursor for synthesizing novel antiviral and anticancer agents. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Development: Used in research for creating potential therapeutics targeting viral polymerases and reverse transcriptases.
• Oncology Research: Serves as a building block for developing purine-based chemotherapeutic agents and targeted cancer therapies.
• Biochemical Research: Employed in studies of enzyme mechanisms, nucleic acid metabolism, and as a tool compound in molecular biology.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Radiopharmaceuticals: Potential precursor for the synthesis of fluorine-18 labeled tracers for Positron Emission Tomography (PET) imaging.

Basic Information

Item	Details
Product Name	8-Amino-6-Fluoro-9-Ribofuranosyl-9H-Purine
CAS No.	97229-54-4
Molecular Formula	C10H12FN5O4
Molecular Weight	285.23 g/mol
Synonyms	8-Amino-6-fluoropurine riboside; 6-Fluoro-9-β-D-ribofuranosyl-9H-purin-8-amine; 8-Amino-6-fluoro-9-β-D-ribofuranosylpurine; 8-Amino-6-fluoroguanosine; 6-Fluoro-8-aminoguanosine; 8-Amino-6-fluoronebularine; 8-Amino-6-fluoro-9-(β-D-ribofuranosyl)purine; 8-Amino-6-fluoro-9-(β-D-ribofuranosyl)-9H-purine
EINECS	Contact for details

Quality Control

Our 8-Amino-6-Fluoro-9-Ribofuranosyl-9H-Purine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and pharmaceutical development. Products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.