Description

(2S)-2-{[(Benzyloxy)Carbonyl]Amino}-2-Methyl-3-Phenylpropanoic Acid is a high-purity, non-natural amino acid derivative featuring a Cbz-protected amino group and a chiral center. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling the introduction of sterically hindered, unnatural amino acid motifs. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic agents, including enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a sterically hindered, non-proteinogenic amino acid residue into peptide chains.
• Protease Inhibitor Development: Serves as a core structural component in the design and synthesis of potent inhibitors for various proteases (e.g., renin, HIV protease).
• Chemical Biology Research: Employed as a tool compound to study protein-protein interactions and enzyme mechanisms by introducing specific steric and electronic constraints.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in asymmetric synthesis to control stereochemistry in complex organic molecules.
• Bioconjugation: The carboxylic acid functionality allows for conjugation to other molecules, carriers, or surfaces for creating targeted bioconjugates.

Basic Information

Product Name	(2S)-2-{[(Benzyloxy)Carbonyl]Amino}-2-Methyl-3-Phenylpropanoic Acid
CAS No.	97206-19-4
Molecular Formula	C18H19NO4
Molecular Weight	313.35 g/mol
Synonyms	N-Cbz-2-Amino-2-methyl-3-phenylpropionic acid; (S)-2-((((Benzyloxy)carbonyl)amino)-2-methyl-3-phenylpropanoic acid; N-Carbobenzyloxy-2-amino-2-methyl-3-phenylpropionic acid; Z-2-Amino-2-methyl-3-phenylpropionic acid; (S)-N-Cbz-2-Amino-2-methyl-3-phenylpropanoic acid; (2S)-2-[[(Benzyloxy)carbonyl]amino]-2-methyl-3-phenylpropanoic acid; Cbz-Amp-OH; Z-Amp-OH
EINECS	Contact for details

Quality Control

Our (2S)-2-{[(Benzyloxy)Carbonyl]Amino}-2-Methyl-3-Phenylpropanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.