Description

2-(Trimethylsilyl)Ethanol is a versatile organosilicon compound featuring both a reactive hydroxyl group and a hydrolytically stable trimethylsilyl moiety. This unique bifunctional structure makes it a valuable intermediate and protecting group reagent in advanced organic synthesis. It is essential for manufacturers and R&D chemists in the pharmaceutical, agrochemical, and specialty materials sectors seeking to introduce silyl functionality or create silicon-containing building blocks.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, often serving as a protecting group for alcohols or as a precursor for silicon-based drug candidates.
• Agrochemical Synthesis: Acts as a key building block in the production of advanced pesticides, herbicides, and fungicides that incorporate organosilicon chemistry for enhanced efficacy or stability.
• Polymer & Material Science: Employed as a monomer or modifier in the synthesis of silicone resins, hybrid organic-inorganic polymers, and surface-modifying agents to alter material properties like hydrophobicity or adhesion.
• Cross-Coupling Reagents: Serves as a reagent in various metal-catalyzed cross-coupling reactions, facilitating the introduction of the 2-(trimethylsilyl)ethyl group into complex molecules.
• Protecting Group Chemistry: The 2-(trimethylsilyl)ethoxy (SEM) group, derived from this compound, is a widely used protecting group for alcohols, phenols, and carboxylic acids in multi-step syntheses, particularly for acid- and base-sensitive substrates.
• Surface Modification: Used to functionalize silica, glass, or other oxide surfaces, creating hydrophobic coatings or providing anchor points for further chemical grafting.

Basic Information

Product Name	2-(Trimethylsilyl)Ethanol
CAS No.	97203-62-8
Molecular Formula	C5H14OSi
Molecular Weight	118.25 g/mol
Synonyms	2-(Trimethylsilyl)ethanol; 2-(Trimethylsilyl)ethyl alcohol; β-(Trimethylsilyl)ethanol; Hydroxyethyltrimethylsilane; Trimethyl(2-hydroxyethyl)silane; 2-Hydroxyethyltrimethylsilane; TMS-Ethanol; SEM-OH (2-(Trimethylsilyl)ethoxymethanol precursor)
EINECS	Contact for details

Quality Control

Our 2-(Trimethylsilyl)Ethanol is produced and handled under a strict quality management system. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can lead to decomposition. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.