Description

[6R-[6α,7β(E)]]-7-[[(2-Amino-4-Thiazolyl)[(Carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is a key advanced pharmaceutical intermediate in the synthesis of modern cephalosporin antibiotics. This compound is critical for developing broad-spectrum antibacterial agents with enhanced stability against β-lactamases. It is primarily required by pharmaceutical R&D departments and active pharmaceutical ingredient (API) manufacturers focused on next-generation infection treatments.

Application

• Pharmaceutical Intermediate: Core building block for the synthesis of third and fourth-generation cephalosporin antibiotics.
• Antibacterial API Synthesis: Used in the production of active pharmaceutical ingredients targeting resistant bacterial strains.
• Research & Development: Serves as a critical reference standard and starting material in antimicrobial drug discovery programs.
• Process Chemistry: Employed in scale-up and optimization of antibiotic manufacturing processes.
• Veterinary Medicine: Potential use in developing antibacterial treatments for animal health.

Basic Information

Product Name	[6R-[6α,7β(E)]]-7-[[(2-Amino-4-Thiazolyl)[(Carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS No.	97164-56-2
Molecular Formula	C18H17N5O7S2
Molecular Weight	479.49 g/mol
Synonyms	(6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-vinyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Ceftiofur Intermediate; Ceftiofur Acid; 7-ACA Derivative; 3-Vinylcephem Derivative; (6R-trans)-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our pharmaceutical-grade intermediates are produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for API synthesis. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.