Description

Methyl 17,20-Acetonidodihydroprednisolonate is a high-purity synthetic steroid derivative, specifically a methylated and acetonide-protected form of dihydroprednisolone. This compound is valued for its role as a critical pharmaceutical intermediate in the synthesis of advanced corticosteroid APIs, offering precise chemical functionality for targeted modifications. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent topical and systemic corticosteroids.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new steroid-based drugs with improved efficacy and reduced side effects.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Process Chemistry: Employed in scale-up and optimization of API manufacturing processes under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	Methyl 17,20-Acetonidodihydroprednisolonate
CAS No.	97142-19-3
Molecular Formula	C25H34O6
Molecular Weight	430.53 g/mol
Synonyms	Methyl 17,20-Acetonide of Dihydroprednisolone; 17,20-Acetonidodihydroprednisolonate Methyl Ester; 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione 17,20-Acetonide 21-Methyl Ester; Prednisolone 17,20-Acetonide Methyl Ester (Dihydro); 1,4-Pregnadiene-3,20-dione, 11,17,21-trihydroxy-, 17,20-acetonide, 21-methyl ester, (11β)-; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Methyl 17,20-Acetonidodihydroprednisolonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment to ensure compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.