Description

1-Chloro-1-(3-Trifluoromethyl-Phenyl)-Propan-2-One is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity of the α-chloroketone group and the electron-withdrawing trifluoromethyl substituent, enabling precise molecular construction. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers and specialty polymers with tailored optical or electronic properties.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	1-Chloro-1-(3-Trifluoromethyl-Phenyl)-Propan-2-One
CAS No.	97132-58-6
Molecular Formula	C10H8ClF3O
Molecular Weight	236.62 g/mol
Synonyms	1-Chloro-1-[3-(trifluoromethyl)phenyl]propan-2-one; 2-Propanone, 1-chloro-1-[3-(trifluoromethyl)phenyl]-; 3'-Trifluoromethylphenacyl chloride; α-Chloro-3'-(trifluoromethyl)acetophenone; 1-Chloro-1-(3-trifluoromethylphenyl)acetone; 2-Chloro-1-(3-(trifluoromethyl)phenyl)ethanone (tautomeric form); m-Trifluoromethylphenacyl chloride
EINECS	Contact for details

Quality Control

Our 1-Chloro-1-(3-Trifluoromethyl-Phenyl)-Propan-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber glass, or in secondary light-proof packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 96.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.