Description

(R)-(+)-4-Chloromandelonitrile is a high-value chiral intermediate and building block in organic synthesis. This compound matters for its role as a key precursor in the production of enantiomerically pure pharmaceuticals and agrochemicals, where the specific (R)-configuration is critical for biological activity. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of enantiopure drugs, particularly in cardiovascular and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides, where the specific stereochemistry enhances efficacy and reduces environmental impact.
• Asymmetric Catalysis: Serves as a starting material or ligand precursor in asymmetric synthesis to create other chiral molecules with high enantiomeric excess.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances that require a defined stereochemical center.
• Academic & Industrial R&D: Utilized in research laboratories for method development and exploring new synthetic pathways in medicinal chemistry.

Basic Information

Product Name	(R)-(+)-4-Chloromandelonitrile
CAS No.	97070-79-6
Molecular Formula	C8H6ClNO
Molecular Weight	167.59 g/mol
Synonyms	(R)-(+)-4-Chloromandelonitrile; (R)-4-Chloromandelonitrile; (R)-α-Hydroxy-4-chlorobenzeneacetonitrile; (R)-(+)-α-Hydroxy-p-chlorophenylacetonitrile; (R)-p-Chloromandelonitrile; (R)-4-Chlorobenzaldehyde cyanohydrin; (R)-(4-Chlorophenyl)(hydroxy)acetonitrile; (R)-Cyanohydrin of 4-chlorobenzaldehyde
EINECS	Contact for details

Quality Control

Our (R)-(+)-4-Chloromandelonitrile is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard identification tests, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing purity, chiral assay, and impurity profiles are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.