Description

14-Hydroxypregna-1,4-Diene-3,20-Dione is a high-purity steroid intermediate of significant importance in pharmaceutical synthesis. This compound serves as a critical building block for the development of advanced corticosteroid and progestogen-based active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the production of specialized steroid therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent corticosteroid drugs, including anti-inflammatory and immunosuppressive agents.
• Steroid API Development: Used in research and development for creating novel steroid-based active pharmaceutical ingredients with targeted therapeutic effects.
• Biochemical Research: Serves as a reference standard or starting material in studies investigating steroid hormone pathways, receptor binding, and metabolic processes.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale manufacturing for established steroid pharmaceuticals, ensuring efficient and reproducible synthesis routes.
• Custom Synthesis: Utilized by fine chemical suppliers for the custom manufacturing of specialized steroid derivatives for preclinical and clinical studies.

Basic Information

Product Name	14-Hydroxypregna-1,4-Diene-3,20-Dione
CAS No.	97055-11-3
Molecular Formula	C21H28O3
Molecular Weight	328.45 g/mol
Synonyms	14-Hydroxy-1,4-pregnadiene-3,20-dione; 14α-Hydroxyprednisone; 14-Hydroxyprednisone; 14-Hydroxy Steroid Intermediate; 14-OH-Prednisone; 14-Hydroxy-1,4-pregnadiene-3,11,20-trione derivative; 14-Hydroxy Steroid Dione
EINECS	Contact for details

Quality Control

Our 14-Hydroxypregna-1,4-Diene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) documenting full specifications are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.