Description

n-Desacetyl 3-Demethyl Thiocolchicine CAS NO 97043-09-9 is a chemically modified derivative of the natural alkaloid colchicine, where specific acetyl and methyl groups have been removed and a sulfur atom has been introduced. This structural modification is of significant interest for creating novel bioactive compounds with potentially altered pharmacological profiles. It serves as a critical pharmaceutical intermediate and a valuable research chemical for medicinal chemistry programs, particularly in oncology and anti-inflammatory drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel colchicine analogs and prodrugs for therapeutic development.
• Medicinal Chemistry Research: Used as a reference standard and precursor in structure-activity relationship (SAR) studies to investigate tubulin binding and inhibition.
• Biochemical Research: Employed in vitro studies to explore mechanisms of cell cycle arrest and apoptosis.
• Academic & Institutional R&D: Utilized by universities and research institutes for fundamental studies in chemical biology and pharmacology.
• Contract Research Organization (CRO) Services: Supplied to CROs conducting client-sponsored drug discovery and development projects.

Basic Information

Product Name	n-Desacetyl 3-Demethyl Thiocolchicine
CAS No.	97043-09-9
Molecular Formula	C20H21NO4S
Molecular Weight	371.45 g/mol
Synonyms	3-Demethylthiocolchicine; N-Desacetyl-3-demethylthiocolchicine; Thiocolchicine derivative; 7-Deacetyl-10-demethylthiocolchicine; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide thio analog; Colchiceinamide, thio-; 3-Demethyl-N-desacetylthiocolchicine
EINECS	Contact for details

Quality Control

Our n-Desacetyl 3-Demethyl Thiocolchicine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific results for all critical parameters. Our quality commitment ensures material suitable for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.