Description

n-(Ethoxyacetyl)Deacetylthiocolchicine is a semi-synthetic derivative of the natural alkaloid colchicine, specifically modified to explore enhanced pharmacological profiles and structure-activity relationships. This compound is of significant interest in advanced pharmaceutical research and development, particularly in the study of tubulin polymerization inhibitors and their therapeutic potential. It serves as a critical intermediate and reference standard for researchers and manufacturers in the fields of oncology, anti-inflammatory drug discovery, and chemical biology.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel colchicine analogs for therapeutic development.
• Research Chemical: Used in biochemical and pharmacological research to study mechanisms of tubulin binding and mitosis inhibition.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in laboratory settings.
• Drug Discovery Programs: Employed in screening libraries and structure-activity relationship (SAR) studies to identify new anti-cancer and anti-gout agents.
• Academic Research: Utilized in university and institutional labs for fundamental studies in cell biology and medicinal chemistry.

Basic Information

Product Name	n-(Ethoxyacetyl)Deacetylthiocolchicine
CAS No.	97043-02-2
Molecular Formula	C24H27NO6S
Molecular Weight	457.54 g/mol
Synonyms	N-(Ethoxyacetyl)deacetylthiocolchicine; Deacetylthiocolchicine N-ethoxyacetate; Thiocolchicine derivative; 3-Demethylthiocolchicine N-ethoxyacetate; Colchicine analog; Tubulin inhibitor intermediate; 7-Acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-9-(methoxycarbonyl)-5-thiophenobenzocyclohepten-4-yl ethyl glycolate
EINECS	Contact for details

Quality Control

Our n-(Ethoxyacetyl)Deacetylthiocolchicine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and specifications can be aligned with client requirements for specific projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.