Description

n-(Methoxycarbonyl)-L-Serine Methyl Ester is a high-purity, protected serine derivative used as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex peptide structures and other biologically active molecules, offering precise stereochemical control. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for developing novel therapeutics and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs, protease inhibitors, and other active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected serine residue to prevent unwanted side reactions.
• Bioconjugation Chemistry: Serves as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Protecting Group Strategy: The methoxycarbonyl (Moc) group provides orthogonal protection for the amino and carboxyl functionalities during multi-step synthetic sequences.
• Chemical Biology Research: Employed in the design and synthesis of enzyme inhibitors, substrate analogs, and molecular probes for biochemical studies.
• Fine Chemical Production: A precursor in the manufacture of specialty surfactants, chiral ligands for catalysis, and advanced materials.

Basic Information

Product Name	n-(Methoxycarbonyl)-L-Serine Methyl Ester
CAS No.	96854-24-9
Molecular Formula	C7H11NO5
Molecular Weight	189.17 g/mol
Synonyms	L-Serine, N-(methoxycarbonyl)-, methyl ester; Methyl N-(methoxycarbonyl)-L-serinate; N-Carbomethoxy-L-serine methyl ester; N-Methoxycarbonyl-L-serine methyl ester; (S)-Methyl 2-((methoxycarbonyl)amino)-3-hydroxypropanoate; Serine derivative (protected); Moc-Ser-OMe; CAS 96854-24-9
EINECS	Contact for details

Quality Control

Our n-(Methoxycarbonyl)-L-Serine Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the stringent requirements for pharmaceutical R&D and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.