Description

N,N'-Bis(Carbobenzyloxy)Lysylserine Methyl Ester is a protected dipeptide derivative, specifically a lysylserine methyl ester with carbobenzyloxy (Cbz) protecting groups on both the alpha and epsilon amines of the lysine residue. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled construction of complex peptides and proteins. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, biochemical probes, and novel biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the sequential assembly of peptide chains containing lysine and serine residues.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormones, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation & Labeling: Serves as a precursor for creating functionalized peptides for antibody-drug conjugates (ADCs) or diagnostic imaging agents.
• Biochemical Research: Employed in studies of protein structure-function relationships and the synthesis of custom peptide substrates or inhibitors.
• Fine Chemical Production: An essential raw material for contract manufacturing organizations (CMOs) specializing in custom peptide APIs and fragments.

Basic Information

Product Name	N,N'-Bis(Carbobenzyloxy)Lysylserine Methyl Ester
CAS No.	96849-75-1
Molecular Formula	C32H45N3O9
Molecular Weight	615.72 g/mol
Synonyms	Nα,Nε-Bis-Cbz-L-lysyl-L-serine methyl ester; N,N'-Di-Cbz-Lys-Ser-OMe; Methyl N,N'-bis(benzyloxycarbonyl)-L-lysyl-L-serinate; (2S)-2-[[(2S)-6-[[(Benzyloxy)carbonyl]amino]-2-[[(benzyloxy)carbonyl]amino]hexanoyl]amino]-3-hydroxypropanoic acid methyl ester; Lys(2Cl-Z)-Ser-OMe; Boc-Lys(Cbz)-Ser-OMe (common naming variant); Z-Lys(Z)-Ser-OMe
EINECS	Contact for details

Quality Control

Our N,N'-Bis(Carbobenzyloxy)Lysylserine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We can supply material compliant with cGMP guidelines for advanced pharmaceutical research upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.