Description

(5E,9E,14E)-8,11,12-Trihydroxyicosa-5,9,14-Trienoic Acid is a specialized polyhydroxy fatty acid derivative with significant biological activity. This compound is valued for its role as a key intermediate in the synthesis of bioactive lipid mediators and for its utility in biochemical research. It is primarily sought by manufacturers and researchers in the pharmaceutical, biotechnology, and advanced chemical synthesis sectors for developing novel therapeutic agents and conducting metabolic pathway studies.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of specialized pro-resolving mediators (SPMs) and other bioactive lipid molecules with anti-inflammatory properties.
• Biochemical Research: Used as a reference standard or substrate in studies of eicosanoid biosynthesis, lipoxygenase pathways, and cell signaling mechanisms.
• Cosmeceutical Development: Incorporated into advanced skincare formulations targeting inflammation and promoting skin barrier repair due to its bioactive lipid profile.
• Nutraceutical Synthesis: Serves as a precursor in the production of high-value, health-promoting lipid compounds for dietary supplements.
• Academic & Industrial R&D: Essential for laboratories investigating inflammation resolution, lipidomics, and the development of new therapeutic candidates.

Basic Information

Product Name	(5E,9E,14E)-8,11,12-Trihydroxyicosa-5,9,14-Trienoic Acid
CAS No.	96790-36-2
Molecular Formula	C₂₀H₃₄O₅
Molecular Weight	354.48 g/mol
Synonyms	8,11,12-TriHETE; 8,11,12-Trihydroxyeicosatrienoic Acid; (5E,9E,14E)-8,11,12-Trihydroxy-5,9,14-eicosatrienoic Acid; 8(S),11(S),12(S)-TriHETE; 8,11,12-Trihydroxy-5Z,9E,14Z-eicosatrienoic Acid; 5,9,14-Eicosatrienoic acid, 8,11,12-trihydroxy-, (5E,9E,14E)-; Lipoxin pathway intermediate
EINECS	Contact for details

Quality Control

Every batch of (5E,9E,14E)-8,11,12-Trihydroxyicosa-5,9,14-Trienoic Acid is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical documentation to ensure product identity, purity, and consistency for your critical applications. A Certificate of Analysis (COA) detailing specifications such as purity (by HPLC), stereochemical configuration, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Store away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Isomeric Purity (Stereochemistry)	≥ 98.0% (8S,11S,12S)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.