Description

7(R)-Amino-3-(1-Pyridiniomethyl)-3-Cephem-4-Carboxylic Acid Chloride Monohydrochloride is a key advanced pharmaceutical intermediate (API intermediate) in the synthesis of third-generation cephalosporin antibiotics. Its primary value lies in enabling the production of potent, broad-spectrum antibiotics with enhanced stability against β-lactamases. This high-purity intermediate is essential for manufacturers in the pharmaceutical industry, particularly those developing and producing injectable cephalosporin drugs to meet stringent global pharmacopeial standards.

Application

• Critical Intermediate for Cephalosporin Synthesis: Serves as a core building block in the chemical synthesis of advanced cephalosporin antibiotics.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the production of final drug substances for injectable antibiotic formulations.
• Research & Development: Employed in pharmaceutical R&D for developing new antibiotic analogs and improving synthetic routes.
• Production of Third-Generation Cephalosporins: Specifically utilized in manufacturing antibiotics known for their expanded gram-negative coverage.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs and generic drug manufacturers producing cephalosporin-based therapeutics.
• GMP-Compliant Production: Suitable for use in facilities operating under current Good Manufacturing Practice (cGMP) guidelines for regulated markets.

Basic Information

Product Name	7(R)-Amino-3-(1-Pyridiniomethyl)-3-Cephem-4-Carboxylic Acid Chloride Monohydrochloride
CAS No.	96752-43-1
Molecular Formula	C14H16Cl2N4O3S
Molecular Weight	391.27 g/mol
Synonyms	(6R,7R)-7-Amino-3-[(1-pyridinio)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate chloride hydrochloride; 7-ACA Pyridinium Chloride Hydrochloride; 7-Amino-3-(pyridiniomethyl)cephalosporanic Acid Chloride Hydrochloride; 7-ACA-PyHCl; Cephalosporin C-7 Pyridinium Intermediate; 7-ADCA Pyridinium Derivative; 7-ATCA Pyridinium Salt; GCLE Pyridinium Intermediate
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality management systems to ensure batch-to-batch consistency and purity suitable for pharmaceutical synthesis. Certificates of Analysis (COA) are provided with each shipment, detailing comprehensive testing results. Our quality standards align with the requirements of major pharmacopeias, and production can be adapted to meet specific cGMP or customer-specific quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.