Description

6-Methylprednisolone-21-Hemisuberate N,N,N'-Triethylenediamine Amide is a chemically modified derivative of the potent glucocorticoid methylprednisolone, designed to enhance specific physicochemical properties for advanced pharmaceutical development. This compound is crucial for researchers and formulators seeking to improve drug solubility, stability, or to create novel prodrug systems for targeted therapeutic delivery. It serves as a key synthetic intermediate and active pharmaceutical ingredient (API) for the development of high-potency anti-inflammatory and immunosuppressive medications, primarily targeting the pharmaceutical, biotechnology, and advanced chemical synthesis sectors.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel corticosteroid-based prodrugs and high-potency APIs.
• Anti-inflammatory Drug Research: Used in R&D for developing next-generation topical and systemic treatments for conditions like dermatitis, arthritis, and autoimmune disorders.
• Prodrug Development: The hemisuberate amide structure is engineered to modify pharmacokinetic profiles, such as enhancing lipophilicity or enabling site-specific activation.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory compliance in pharmaceutical manufacturing.
• Bioconjugation Studies: Utilized in research exploring the conjugation of steroid molecules to carriers or other bioactive molecules.
• Formulation Excipient: Can be investigated for its potential role in improving the stability and delivery of complex pharmaceutical formulations.

Basic Information

Product Name	6-Methylprednisolone-21-Hemisuberate N,N,N'-Triethylenediamine Amide
CAS No.	96608-40-1
Molecular Formula	C33H52N4O7
Molecular Weight	616.80 g/mol
Synonyms	Methylprednisolone 21-Hemisuberate Triethylenediamine Amide; 6α-Methylprednisolone 21-Hemisuberate N,N,N'-Triethylenediamine Amide; 6-Methylprednisolone 21-Hemisuccinate Triethylenediamine Amide; 11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-Hemisuberate N,N,N'-Triethylenediamine Amide; Methylprednisolone Succinate Triethylenediamine Amide; 6-Methylprednisolone Hemisuccinate TED Amide; 96608-40-1; 6-Methylprednisolone-21-Hemisuberate TED Amide
EINECS	Contact for details

Quality Control

Our 6-Methylprednisolone-21-Hemisuberate N,N,N'-Triethylenediamine Amide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure compliance with pharmaceutical-grade standards. Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability and batch-to-batch consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can compromise stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.