Description

Dehydro Felodipine Ester Lactone is a key pharmaceutical intermediate and a structural analog of the calcium channel blocker Felodipine. This compound is of significant value in the research and development of cardiovascular drugs, serving as a crucial building block for synthesizing novel active pharmaceutical ingredients (APIs) and for conducting metabolic studies. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of Felodipine and its structural analogs.
• Medicinal Chemistry Research: Used as a reference standard and building block for developing new calcium channel blockers.
• Metabolite Studies: Employed in the investigation of the metabolic pathways and degradation products of Felodipine.
• Process Development & Scale-up: Serves as a key material for optimizing synthetic routes and scaling up production in fine chemical manufacturing.
• Analytical Reference Standard: Used in quality control laboratories for method development and impurity profiling via HPLC, LC-MS, etc.
• Academic Research: Utilized in university and institutional research for studying dihydropyridine chemistry and drug-receptor interactions.

Basic Information

Item	Detail
Product Name	Dehydro Felodipine Ester Lactone
CAS No.	96558-27-9
Molecular Formula	C18H19Cl2NO4
Molecular Weight	384.26 g/mol
Synonyms	Dehydro Felodipine Lactone; Felodipine Dehydro Ester Lactone; 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester Lactone; 2,6-Dimethyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic Acid 3-Ethyl 5-Methyl Ester Lactone; Felodipine Impurity; Felodipine Related Compound
EINECS	Contact for details

Quality Control

Our Dehydro Felodipine Ester Lactone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.