Description

tert-Butyl-4-Cbz-Piperazine-2-Carboxylate is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. This compound matters because it provides a versatile and reactive scaffold for constructing complex pharmaceutical molecules, particularly in the development of new active pharmaceutical ingredients (APIs). It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for creating novel compounds with potential therapeutic applications.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Peptidomimetic Synthesis: Used to introduce constrained piperazine motifs into peptide backbones to enhance metabolic stability and bioavailability.
• Medicinal Chemistry Scaffold: Serves as a versatile core structure for constructing libraries of small molecules in high-throughput screening and lead optimization.
• Protecting Group Strategy: The tert-butyl and Cbz (carboxybenzyl) groups allow for orthogonal protection/deprotection sequences in multi-step synthetic routes.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and insecticides that require complex heterocyclic architectures.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized fine chemicals.

Basic Information

Product Name	tert-Butyl-4-Cbz-Piperazine-2-Carboxylate
CAS No.	96558-17-7
Molecular Formula	C17H24N2O4
Molecular Weight	320.39 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-(benzyloxycarbonyl)piperazine-2-carboxylic acid; 4-(Benzyloxycarbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid; 1-Boc-4-Cbz-piperazine-2-carboxylic acid; Boc-Cbz-Pip-OH; tert-Butyl 4-[(benzyloxy)carbonyl]-2-piperazinecarboxylate; 2-Piperazinecarboxylic acid, 4-[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester; 4-Cbz-1-Boc-piperazine-2-carboxylic acid; N-Boc-N'-Cbz-piperazine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our tert-Butyl-4-Cbz-Piperazine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material is suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.