Description

(2R,5S)-5-Amino-8-Guanidino-4-Oxo-2-Phenylmethyloctanoic Acid Sulfate is a high-purity, non-proteinogenic amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral building block and a key intermediate in the synthesis of complex bioactive molecules, particularly protease inhibitors. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutic agents, where precise stereochemistry and high chemical purity are paramount for successful outcomes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel protease inhibitors and other peptide-based therapeutics.
• Biochemical Research: Used as a substrate or inhibitor analog in enzymatic studies to investigate protease mechanisms and kinetics.
• Medicinal Chemistry: Serves as a core structural motif for structure-activity relationship (SAR) studies in drug discovery programs targeting specific enzymes.
• Peptidomimetic Development: Employed in the design and synthesis of peptidomimetics, which are molecules that mimic the structure and function of natural peptides but with enhanced stability and bioavailability.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical manufacturing and regulatory submissions.

Basic Information

Product Name	(2R,5S)-5-Amino-8-Guanidino-4-Oxo-2-Phenylmethyloctanoic Acid Sulfate
CAS No.	96551-81-4
Molecular Formula	C₁₆H₂₆N₆O₆ • H₂SO₄
Molecular Weight	494.50 g/mol (for free base, contact for salt form details)
Synonyms	5-Amino-8-guanidino-4-oxo-2-(phenylmethyl)octanoic acid sulfate; (2R,5S)-5-Amino-8-guanidino-4-oxo-2-(phenylmethyl)octanoic acid sulfate; 2-Benzyl-5-amino-8-guanidino-4-oxooctanoic acid sulfate; NSC 339313; A potent intermediate for protease inhibitor synthesis; (2R,5S)-AGOPS; Octanoic acid derivative sulfate salt
EINECS	Contact for details

Quality Control

Our (2R,5S)-5-Amino-8-Guanidino-4-Oxo-2-Phenylmethyloctanoic Acid Sulfate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards and can support development activities requiring material for pre-clinical and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.