Description

o-Methyl Chlorthalidone CAS NO 96512-76-4 is a key chemical intermediate and derivative of the diuretic agent chlorthalidone. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and for metabolic studies. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in cardiovascular and renal drug discovery.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of advanced chlorthalidone analogs and related therapeutic agents.
• Metabolite Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for pharmacokinetic and bioanalytical studies.
• Research & Development: Employed in medicinal chemistry programs to explore structure-activity relationships (SAR) for diuretic and antihypertensive compounds.
• Impurity Standard: Serves as a qualified impurity standard for quality control testing of chlorthalidone API batches, ensuring compliance with ICH guidelines.
• Chemical Synthesis: Utilized in organic synthesis for introducing specific functional groups or modifying the chlorthalidone core structure.

Basic Information

Product Name	o-Methyl Chlorthalidone
CAS No.	96512-76-4
Molecular Formula	C15H13ClN2O4S
Molecular Weight	352.79 g/mol
Synonyms	2-Chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzenesulfonamide, O-Methyl Derivative; 3-(4-Chloro-3-sulfamoylphenyl)-3-hydroxy-1-methylisoindolin-1-one; Chlorthalidone O-Methyl Derivative; Chlorthalidone Impurity; Chlorthalidone Related Compound; 1-Oxo-1,3-dihydro-2H-isoindole Derivative
EINECS	Contact for details

Quality Control

Our o-Methyl Chlorthalidone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing compliance with in-house specifications suitable for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.