Description

10-Ketonaltrexone is a key pharmaceutical intermediate and research chemical with significant importance in medicinal chemistry and neuropharmacology. Its primary value lies in its role as a precursor in the synthesis of naltrexone and related opioid antagonists, which are critical for treating addiction and alcohol dependence. This compound is essential for pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic institutions focused on developing new therapeutic agents targeting the opioid receptor system.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of Naltrexone, an opioid receptor antagonist.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop novel opioid antagonists with improved efficacy and safety profiles.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Employed in vitro studies to investigate the binding mechanisms and metabolic pathways of opioid receptor ligands.
• Process Development: Utilized for scaling up and optimizing manufacturing processes for naltrexone-based APIs in GMP environments.

Basic Information

Product Name	10-Ketonaltrexone
CAS No.	96445-14-6
Molecular Formula	C20H23NO4
Molecular Weight	341.40 g/mol
Synonyms	17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one; 10-Oxonaltrexone; Noroxymorphone cyclopropylmethyl ketone; 6-Oxo-naltrexone; 10-Keto naltrexone; CP-45,634
EINECS	Contact for details

Quality Control

Our 10-Ketonaltrexone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.