Description

10-Oxo Naltrexone is a key pharmaceutical intermediate and research chemical, specifically a derivative of naltrexone. This compound is of significant interest in medicinal chemistry for the development and study of novel opioid receptor antagonists and related therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in the synthesis of advanced active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced opioid receptor modulators and related pharmaceutical compounds.
• Medicinal Chemistry Research: Used as a reference standard and precursor in the study of structure-activity relationships (SAR) for opioid antagonists.
• Biochemical Research: Employed in receptor binding assays and pharmacological studies to investigate opioid receptor mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Process Development: Utilized in the scale-up and optimization of synthetic routes for naltrexone-derived pharmaceuticals.

Basic Information

Product Name	10-Oxo Naltrexone
CAS No.	96445-13-5
Molecular Formula	C20H23NO4
Molecular Weight	341.41 g/mol
Synonyms	10-Oxonaltrexone; 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one; 6-Oxonaltrexone; Naltrexone Impurity F; Noroxymorphone-17-cyclopropylmethyl ketone; 4,5α-Epoxy-3,14-dihydroxy-17-(cyclopropylmethyl)morphinan-6-one
EINECS	Contact for details

Quality Control

Our 10-Oxo Naltrexone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets stringent specifications for research and pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.