Description

Methyl (3S)-3-Amino-5-Methylhexanoate Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its primary value lies in its role as a key precursor in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular conditions. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel therapeutics and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of advanced drug candidates and APIs.
• Peptidomimetic Research: Serves as a constrained amino acid ester derivative for constructing novel peptide analogs and mimetics in medicinal chemistry.
• Asymmetric Synthesis: Utilized as a starting material or reagent in catalytic asymmetric transformations to introduce stereochemical complexity.
• Bioconjugation & Prodrug Development: The methyl ester and amine functionalities enable its use in linker chemistry for creating targeted prodrugs or bioconjugates.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Scale-Up: Supplied to CDMOs and fine chemical manufacturers for custom synthesis projects from gram to kilogram scale.

Basic Information

Product Name	Methyl (3S)-3-Amino-5-Methylhexanoate Hydrochloride
CAS No.	96386-93-5
Molecular Formula	C9H20ClNO2
Molecular Weight	209.71 g/mol
Synonyms	(3S)-3-Amino-5-methylhexanoic acid methyl ester hydrochloride; L-Leucine methyl ester derivative hydrochloride; Methyl 3-amino-5-methylhexanoate HCl; (S)-Methyl 3-amino-5-methylhexanoate hydrochloride; 5-Methyl-L-norleucine methyl ester hydrochloride; 3-Amino-5-methylhexanoic acid methyl ester (S)-form hydrochloride; β-Amino acid ester hydrochloride; Chiral β-amino ester salt
EINECS	Contact for details

Quality Control

Our Methyl (3S)-3-Amino-5-Methylhexanoate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing identity, purity (typically >98.5%), enantiomeric excess (>99.0%), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Single Maximum Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.