Description

(2S,4S)-Boc-4-Phenyl-Pyrrolidine-2-Carboxylic Acid CAS NO 96314-29-3 is a high-purity, stereochemically defined chiral building block essential for advanced pharmaceutical synthesis. Its core value lies in serving as a key intermediate for constructing complex molecules with precise three-dimensional architecture, which is critical for developing active pharmaceutical ingredients (APIs) with targeted therapeutic effects. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of novel drugs, particularly in areas like protease inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting viral proteases and neurological disorders.
• Peptidomimetic Research: Used to incorporate constrained proline-like structures into peptide analogs to enhance metabolic stability and receptor selectivity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for developing novel chiral ligands and organocatalysts used in enantioselective transformations.
• Chemical Biology & Probe Development: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Utilized in route scouting and optimization for the commercial-scale manufacturing of chiral APIs.
• Custom Synthesis & Contract Manufacturing: A requested building block for bespoke chemical synthesis services catering to the pharmaceutical and biotechnology industries.

Basic Information

Product Name	(2S,4S)-Boc-4-Phenyl-Pyrrolidine-2-Carboxylic Acid
CAS No.	96314-29-3
Molecular Formula	C₁₇H₂₃NO₄
Molecular Weight	305.37 g/mol
Synonyms	(2S,4S)-1-(tert-Butoxycarbonyl)-4-phenylpyrrolidine-2-carboxylic acid; (2S,4S)-1-Boc-4-phenylpyrrolidine-2-carboxylic acid; (2S,4S)-N-Boc-4-phenylproline; tert-Butyl (2S,4S)-2-carboxy-4-phenylpyrrolidine-1-carboxylate; (S,S)-Boc-4-Phenylpyrrolidine-2-carboxylic Acid; Boc-(S,S)-4-Phenylproline; 1-Boc-4-phenyl-L-proline; (2S,4S)-4-Phenyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (2S,4S)-Boc-4-Phenyl-Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding pharmaceutical R&D and scale-up applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.