Description

trans-4-Phenyl-L-Proline is a non-proteinogenic, chiral proline derivative where a phenyl group is substituted at the 4-position of the pyrrolidine ring. This structural modification makes it a valuable synthetic building block and chiral auxiliary in asymmetric synthesis and pharmaceutical research. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the development of novel active compounds and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of peptidomimetics, protease inhibitors, and other bioactive molecules.
• Asymmetric Catalysis: Serves as a ligand or catalyst component in enantioselective transformations.
• Peptide Chemistry: Used to introduce conformational constraints and enhance metabolic stability in peptide-based drug candidates.
• Chemical Biology Research: Employed as a probe or building block for studying protein structure and function.
• Agrochemical Synthesis: Intermediate in the development of chiral active ingredients for crop protection.
• Academic & R&D: Fundamental research tool in organic and medicinal chemistry for method development and novel compound libraries.

Basic Information

Product Name	trans-4-Phenyl-L-Proline
CAS No.	96314-26-0
Molecular Formula	C11H13NO2
Molecular Weight	191.23 g/mol
Synonyms	(2S,4R)-4-Phenylproline; (2S,4R)-4-Phenyl-2-pyrrolidinecarboxylic Acid; L-trans-4-Phenylproline; trans-4-Phenyl-L-proline; (4R)-4-Phenyl-L-proline; 4-Phenyl-L-proline, trans-; 4-PhPro-OH; 96314-26-0
EINECS	Contact for details

Quality Control

Our trans-4-Phenyl-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.