Description

Z-D-Dbu(Boc)-Oh is a protected amino acid derivative, specifically a Boc-protected derivative of 2,4-diaminobutyric acid (Dbu) with a benzyloxycarbonyl (Z) group on the α-amino function. This compound serves as a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise control over stereochemistry and side-chain functionality. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, medicinal chemistry, and the development of novel therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of 2,4-diaminobutyric acid residues into peptide chains, enabling the study of structure-activity relationships.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of peptide-based pharmaceuticals, enzyme inhibitors, and receptor ligands where the Dbu side chain is pharmacologically relevant.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or affinity probes, leveraging the reactive primary amine on the side chain after selective deprotection.
• Synthesis of Constrained Peptides: Facilitates the introduction of turn-inducing or cyclization elements in peptides due to the structural properties of the diaminobutyric acid scaffold.
• Academic & Industrial Research: Employed in biochemical and biophysical studies to investigate protein-protein interactions, peptide folding, and stability.

Basic Information

Product Name	Z-D-Dbu(Boc)-Oh
CAS No.	96186-30-0
Molecular Formula	C17H24N2O6
Molecular Weight	352.39 g/mol
Synonyms	Nα-Benzyloxycarbonyl-Nω-tert-butoxycarbonyl-D-2,4-diaminobutyric acid; (R)-2-(((Benzyloxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)butanoic acid; Z-D-Dab(Boc)-OH; Boc-D-Dab(Z)-OH; D-2,4-Diaminobutyric acid, Nα-Z, Nω-Boc-; Nα-Cbz-Nω-Boc-D-2,4-diaminobutyric acid
EINECS	Contact for details

Quality Control

Our Z-D-Dbu(Boc)-Oh is manufactured under strict quality control protocols to ensure high chemical purity and chiral integrity, suitable for demanding synthetic applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee consistent quality and traceability for your research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.