Description

1-(Chloroacetyl)-D-Proline Ethyl Ester is a high-purity chiral building block and pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking high-quality, stereochemically defined intermediates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of protease inhibitors and other chiral APIs.
• Peptidomimetics Research: Used in medicinal chemistry for designing and synthesizing peptide-like molecules with enhanced stability and bioavailability.
• Asymmetric Synthesis: Serves as a chiral auxiliary or precursor in stereoselective chemical reactions.
• Agrochemical Development: Intermediate in the production of advanced, optically active crop protection agents.
• Custom Synthesis: Starting material for contract research organizations (CROs) and CDMOs producing bespoke fine chemicals.
• Bioconjugation Chemistry: Potential use in linker chemistry for antibody-drug conjugates (ADCs) due to its reactive chloroacetyl group.

Basic Information

Product Name	1-(Chloroacetyl)-D-Proline Ethyl Ester
CAS No.	96163-73-4
Molecular Formula	C9H14ClNO3
Molecular Weight	219.66 g/mol
Synonyms	D-Proline, 1-(chloroacetyl)-, ethyl ester; Ethyl 1-(chloroacetyl)-D-prolinate; (R)-1-(Chloroacetyl)pyrrolidine-2-carboxylic acid ethyl ester; Ethyl (R)-1-(2-chloroacetyl)pyrrolidine-2-carboxylate; 96163-73-4; D-Proline ethyl ester, N-chloroacetyl-; N-Chloroacetyl-D-proline ethyl ester
EINECS	Contact for details

Quality Control

Our 1-(Chloroacetyl)-D-Proline Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.