Description

D-Proline, Ethyl Ester (9Ci) is a non-natural, enantiomerically pure amino acid derivative, specifically the ethyl ester of D-proline. This compound is a crucial chiral building block and intermediate in organic synthesis, offering high stereochemical purity for the construction of complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, chiral catalysts, and other bioactive compounds where the D-proline scaffold is required.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of active pharmaceutical ingredients (APIs), particularly for peptide drugs and protease inhibitors.
• Organocatalyst Precursor: Used in the preparation of chiral organocatalysts for enantioselective transformations in fine chemical synthesis.
• Peptide Research: Employed in solid-phase and solution-phase peptide synthesis to incorporate the D-proline configuration, which can influence peptide conformation and biological activity.
• Chemical Biology Probes: Serves as a building block for labeled peptides and molecular probes used in biochemical and cellular studies.
• Agrochemical Synthesis: An intermediate in the development of chiral herbicides and plant growth regulators.
• Academic & R&D: Used in university and industrial research laboratories for methodological development in asymmetric synthesis and medicinal chemistry projects.

Basic Information

Product Name	D-Proline, Ethyl Ester (9Ci)
CAS No.	96163-72-3
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	Ethyl D-prolinate; D-Proline ethyl ester; (R)-(-)-Proline ethyl ester; (R)-Pyrrolidine-2-carboxylic acid ethyl ester; (-)-Proline ethyl ester; D-(-)-Proline ethyl ester; Proline, ethyl ester, D-; 2-Pyrrolidinecarboxylic acid, ethyl ester, (2R)-
EINECS	Contact for details

Quality Control

Our D-Proline, Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.