Description

3,3,3-Trifluoroalanine Hydrochloride is a high-value, non-natural amino acid derivative characterized by the presence of a trifluoromethyl group. This compound is a critical building block in medicinal chemistry and agrochemical research, where its unique fluorine substitution pattern imparts desirable properties such as enhanced metabolic stability and lipophilicity to target molecules. It is primarily sought after by research institutions and industrial R&D departments focused on developing novel pharmaceuticals, particularly protease inhibitors, and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated peptide analogs and active pharmaceutical ingredients (APIs), especially in protease inhibitor research.
• Agrochemical Research: Used in the synthesis of novel herbicides and pesticides, where the fluorine atoms can improve biological activity and environmental persistence.
• Biochemical Tool Compound: Serves as a substrate or inhibitor in enzymatic studies to investigate amino acid metabolism and enzyme specificity.
• Peptide Synthesis: Employed in solid-phase and solution-phase peptide synthesis to incorporate fluorinated amino acids, altering the physical and biological properties of peptides.
• Material Science Precursor: Potential use in the synthesis of specialized fluorinated polymers and surface modifiers.
• Diagnostic Agent Development: Can be utilized in the creation of fluorinated probes and contrast agents for imaging technologies.

Basic Information

Product Name	3,3,3-Trifluoroalanine Hydrochloride
CAS No.	96105-72-5
Molecular Formula	C3H5ClF3NO2
Molecular Weight	179.52 g/mol
Synonyms	3,3,3-Trifluoro-DL-alanine hydrochloride; (RS)-2-Amino-3,3,3-trifluoropropanoic acid hydrochloride; 3,3,3-Trifluoroalanine HCl; DL-3,3,3-Trifluoroalanine hydrochloride; Tfa-OH·HCl; 2-Amino-3,3,3-trifluoropropionic acid hydrochloride; α-Amino-β,β,β-trifluoropropionic acid hydrochloride
EINECS	Contact for details

Quality Control

Our 3,3,3-Trifluoroalanine Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.