Description

n-(tert-Butoxycarbonyl)-D-Threonine Methyl Ester is a protected amino acid derivative, specifically a Boc-protected D-threonine methyl ester. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering high stereochemical purity for demanding applications. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of active pharmaceutical ingredients (APIs), therapeutic peptides, and fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the solid-phase and solution-phase synthesis of peptide-based drugs and APIs.
• Peptide Research: Essential building block in academic and industrial research for constructing peptides with specific D-amino acid configurations.
• Protease Inhibitor Development: Used in the design and synthesis of enzyme inhibitors where the D-threonine moiety is crucial for activity.
• Fine Chemical Synthesis: Intermediate in the multi-step synthesis of complex organic molecules requiring protected amino acid derivatives.
• Glycopeptide Synthesis: Serves as a precursor in the preparation of glycosylated peptides and related conjugates.

Basic Information

Product Name	n-(tert-Butoxycarbonyl)-D-Threonine Methyl Ester
CAS No.	96099-84-2
Molecular Formula	C10H19NO5
Molecular Weight	233.26 g/mol
Synonyms	Boc-D-Thr-OMe; Boc-D-Threonine-OMe; (2R,3S)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxybutanoic acid methyl ester; Methyl (2R,3S)-2-[(tert-butoxycarbonyl)amino]-3-hydroxybutanoate; D-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; Boc-D-Threonine methyl ester; (R-(R*,S*))-2-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-hydroxybutanoic acid methyl ester
EINECS	Contact for details

Quality Control

Our n-(tert-Butoxycarbonyl)-D-Threonine Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Specific Rotation	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.